原文传递
An intersubstance approach to drug-concentration-drug effect correlation via metaanalytic data of experimental studies.
| 题名： | An intersubstance approach to drug-concentration-drug effect correlation via metaanalytic data of experimental studies. |
| 作者： | BERGHAUS-G (Cologne Univ, Germany); GRAB-H (Cologne Univ, Germany); STICHT-G (Cologne Univ, Germany) |
| 关键词： | DRUGS-; 2242-; DETECTION-; 9115-; CONCENTRATION-CHEM; 7132-; ANALYSIS-MATH; 6471- |
| 摘要： | Based on a metaanalytical analysis of experimental studies combined with pharmacokinetic data we tried to correlate the time of worst human performance and the time of highest serum-concentration after oral application of several drugs. Critically discussed we can postulate - as a first result - that the dosage does not influence the time of highest concentration but the time of worst performance, and that for substances with short resorption times the maximum of performance decrements is situated after the maximum of concentration and vice versa. For the covering abstract see ITRD E106992. |
| 总页数： | PROCEEDINGS OF T2000 - 15TH CONFERENCE ON ALCOHOL, DRUGS AND TRAFFIC SAFETY, HELD 22-26 MAY 2000, STOCKHOLM, SWEDEN. 2000. pp4 |
| 报告类型： | 科技报告 |
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