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Antihistamines and Driving-Related Behavior: A Review of the Evidence for Impairment.
| 题名： | Antihistamines and Driving-Related Behavior: A Review of the Evidence for Impairment. |
| 作者： | moskowitz, h. wilkinson, c. j. |
| 关键词： | evidence, literature reviews, data bases, drugs |
| 摘要： | A review of the scientific literature concerning the effects of antihistamines on driving-related skills was conducted. After reviewing all pertinent publications from 1998 and earlier, a total of 130 publications were found to meet criteria for inclusion in the data summaries. A data base was created with study results being indexed, and summarized, by specific drug, dose, dosing schedule (i.e., single versus repeated) and H1-antagonist generation as well as by behavioral area or subjective measure. For each H1-antagonist generation, five drugs were evaluated: chlorpheniramine, clemastine, diphenhydramine, hydroxyzine and tripolidine for the 1st-generation, and astemizole, cetirizine, fexofenadine, loratadine and terfenadine for the 2nd-generation. / NOTE: Final rept. Sep 00-Feb 03. / Supplementary Notes: Sponsored by National Highway Traffic Safety Administration, Washington, DC. / Availability Note: Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| 总页数： | u0714；92p |
| 报告类型： | 科技报告 |
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