摘要: |
Algorithms for the management of blunt TBI have been published and widely utilized 1, 2, 3 ,however, no suchalgorithms for the management of penetrating TBI have ever been published. Hence, this proposal for an internationaland multidisciplinary effort to generate new evidence and consensus-based clinical practice guidelines has beenundertaken in conjunction with the Brain Trauma Foundation in Stanford University which has long been a globalleader in clinical practice guideline generation 2 and the Seattle International Brain Injury Consensus Conference(SIBICC) effort 1, 4 . We first convened a steering committee and delineated key topics related to penetrating TBI forevidence-based research on Oct, 2021 and established PICOT (mnemonic derived from clinical research questionelements: Patient, Intervention, Comparison, Outcome and Time) lead questions from which to frame a literaturesearch strategy enumerated in our Yr 1 Qtr 1 report. From the initial series of meetings of internationalmultidisciplinary experts using the Delphi method of consensus, a publication titled “ Rationale and Methods forUpdated Guidelines for the Management of Penetrating TBI” (Hawryluk G et al, 2022) 5 was produced as one of thefirst deliverables. The subaward agreement between co-investigators from Stanford Univ. and Oregon HealthSciences Univ. (OHSU) was finalized on June 15, 2022 which decided on a Statement A (public) distribution of theresulting recommendations in line with their institutions’ research efforts to perform the systematic literature review.The preliminary report of this Literature Review forms the body of this report. This evidence will then form the basisfor the best practice guidelines to be eventually disseminated to civilian and military neurosurgical communities. |