详情

原文传递 Cathartocytosis: A Novel Cellular Process Essential for Metaplastic Dedifferentiation.

题名：	Cathartocytosis: A Novel Cellular Process Essential for Metaplastic Dedifferentiation.
作者：	Brown, J. W.
摘要：	I have discovered that the epitope recognized by mAb Das-1 and which is aberrantly expressed in foregut metaplasia andcancer are two closely related epitopes 3’-Sulfo-LeA and 3’-Sulfo-LeC. The manuscript describing these findings has beenpublished in PLoS ONE and is attached in the appendix. Based on this knowledge we have made significant progress inmolecularly characterizing the process of cathartocytosis annotated by this antigen. Our studies have also suggested that thisepitope may actually play a functional role in cathartocytosis and thus inhibiting its synthesis in high-risk metaplasia andcancer from synthesizing this antigen may have therapeutic potential for esophageal, gastric, and pancreatic cancer. I havealso learned that the proteins that bind these epitopes (Galectin-3, Galectin-4, and Galectin-8 affect metaplasia by inhibitingcathartocytosis (Galectin-3 and Galectin-4) or inhibit differentiation (Galectin-8). I have used these preliminary data to obtainadditional funding (K08 DK132496). Over the last year, I have published an additional 4 papers, presented a lecture about thisresearch at the premier, international gastroenterology conference Digestive Disease Week as well as presented posterselsewhere.
总页数：	69 pages