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原文传递 Chronic Studies of Spinal Cord Stimulation for Restoration of Bladder Function.

题名：	Chronic Studies of Spinal Cord Stimulation for Restoration of Bladder Function.
作者：	Grill, W; Abbott, E.
摘要：	Our objective is to conduct chronic in vivo studies of a novel approach to treat urinary incontinence and poor bladder emptyingfollowing spinal cord injury (SCI). We will measure changes in bladder storage and voiding function produced by epiduralkilohertz-frequency spinal cord stimulation (KHF SCS) in preclinical experiments in rats. This novel mode of SCS is usedsuccessfully to treat chronic pain but has not been developed for treatment of bladder dysfunction. Our acute studies revealedthat KFH SCS at four weeks after complete spinal transection reduced the very large bladder capacities that result from SCI,increased voiding efficiency, and reduce non-voiding contractions. While promising, these experiments were limited to terminalacute studies under anesthesia. To advance this novel therapeutic approach, we are conducting chronic studies of the effectsof KHF SCS on bladder function in awake, behaving animals following either transection or contusion SCI. These studies takeadvantage of our established capacity to deliver on-demand electrical stimulation and continuously monitor bladder pressure,external urethral sphincter (EUS) activity, and voiding behavior in awake, behaving animals.
总页数：	36 pages