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Innovative Approaches to Enhance Chimeric Antigen Receptor (CAR) T-Cell Potency Using Quiescent T Cells.
| 题名： | Innovative Approaches to Enhance Chimeric Antigen Receptor (CAR) T-Cell Potency Using Quiescent T Cells. |
| 作者： | Ghassemi, S. |
| 摘要： | My research focuses on developing Chimeric Antigen Receptor (CAR) T cells for adoptive immunotherapy. The goal of the research is to enhance the efficacyof CAR T therapy by developing potent CAR T cells. Another goal of this research is to shorten the CAR T manufacturing period to increase the availability ofthis therapy in resource constraint health care settings, as well those patients with rapidly progressive disease. CAR T cells are generated by transducingactivated T cells with lentiviral vectors and expanding their progeny over 9-14 days. T cells progressively differentiate over time. Transducing non-activated Tcells with CAR will preserve the intrinsic stem-like properties of naïve and memory T cells. This approach will yield CAR T cells with enhanced replicativecapacity, engraftment, and in vivo activity. The purpose of this work is to determine the optimal T cell subset and corresponding optimal costimulatory domainfor CAR when it is expressed in quiescent T cells. The scope of this research is that CAR T cells generated by transducing quiescent T cells will preserve theintrinsic stem-like properties of naïve and memory T cells. We found that spare respiratory capacity, SRC, is replenished in ICOSZ as well as BBZ CAR Tcells. We also demonstrated that naïve T cell subsets have increased persistence with decreased tumor burden when BBZ CAR T cells is used. |
| 总页数： | 94 pages |
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