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Influences of Intermittent Hyperbaric Oxygen Exposure on Protein Level Changes of Peroxiredoxin 6 in Mouse Lung and Brain
| 题名： | Influences of Intermittent Hyperbaric Oxygen Exposure on Protein Level Changes of Peroxiredoxin 6 in Mouse Lung and Brain |
| 正文语种： | 中文 |
| 作者： | Zhang Yanan Chen Yuliang Wang Zhongzhuang Xu Weigang Li Runping |
| 作者单位： | epartment of iving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, hina |
| 关键词： | Peroxiredoxin 6 intermittent hyperbaric oxygen exposure oxygen toxicity |
| 摘要： | Intermittent exposure to hyperbaric oxygen (HBO) can protect against oxygen toxicity, but little is known about its mechanisms.In this study, we examined the effects of intermittent HBO exposure on the levels of peroxiredoxin 6 (Prdx 6) in lung and brain tissues.Mice were exposed to 280 kPa O2 for 60 min, followed by 30-min exposure to 20% O2/N2 mixture with equal pressure, repeated six times.Then the Prdx 6 protein levels in lung and brain were determined.Compared with normal group, both intermittent and continuous HBO exposures increased Prdx 6 in lung and brain and that these increases were even more significant 24 h after cessation of exposure.There were no obvious differences in Prdx 6 levels for lung and brain from intermittent or continuous groups immediately upon cessation of exposure.However, 24 h after cessation of exposure, Prdx 6 levels in intermittent group were higher than those of continuous group for both lung and brain.Altogether, these data showed that intermittent HBO exposure can increase lung and brain Prdx 6 protein levels, and thereby improve the antioxidant capacity of these tissues. |
| 会议日期： | 201409 |
| 会议举办地点： | 北京 |
| 会议名称： | 2014中国国际潜水、救捞与海洋工程技术论坛 |
| 出版日期： | 2014-08-31 |
| 母体文献： | 2014中国国际潜水、救捞与海洋工程技术论坛论文集 |
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